Meredith
Grey (Ellen Pompeo) – Meredith is the central character and narrates
most of the shows. She began as an intern and is now a resident. She
has had an off and on romance with Derek Shepherd, and they finally
got married by post-it note. She calls herself “dark and stormy,”
mostly due to issues with her alcoholic absent father who she feels
abandoned her many years ago. She also had difficulty reconciling
her mother’s long-term affair with Chief of surgery Richard Webber.
She is best friends with Cristina Yang and they refer to each other
as “my person.” She has a half sister named Lexie and she had
difficulty accepting her when she first came to Seattle Grace
Hospital, but they have slowly grown closer.
Cristina
Yang (Sandra Oh) – Cristina is a cardiothoracic surgery resident who
is an overachiever. Her life revolves around surgery and she has
been known to put surgery before the relationships in her life. She
is best friends with Meredith Grey. For some time, she had a serious
relationship with Preston Burke but he left her on their wedding
day. She is currently in a relationship with Owen Hunt. He had a
relationship with Teddy Altman in Iraq and there is a bit of a love
triangle between the three. Cristina offers to give Owen to Teddy in
order to scrub in on surgery with Altman as her teacher. She later
works through this with Owen.
Derek
Shepherd (Patrick Dempsey) – He was originally the head of
neurosurgery but took over as chief of surgery when Dr. Webber was
“demoted” due to his alcohol issues. He was nicknamed “McDreamy” by
the girls. He came to Seattle Grace to get away from his ex-wife
Addison, who cheated on him with his best friend Mark Sloan. He
began an on-and-off-again relationship with Meredith and they
recently ended up marrying by post it note. He has been having
issues with Webber since he went to the hospital board about
Webber’s drinking problem, resulting in his demotion. They have been
able to come to a truce and appear to be helping each other through
their trials in their new positions.
Alex
Karev (Justin Chambers) – Alex grew up in an unstable home. He
continuously had to protect his mother from his father, who was
abusive. He had numerous flings with different women at Seattle
Grace Hospital until he met a patient named Ava. She came in with
amnesia and he took care of her, eventually falling in love. Ava
left and later spent some time in a mental hospital and they end up
going their separate ways. He later begins to date Izzie and they
got married while she was in the hospital with cancer. After she was
let go from Seattle Grace for performing an incorrect procedure on a
renal patient, causing her to code and almost die. She then
disappeared and left him floundering. He started sleeping with Lexie.
Miranda
Bailey (Chandra Wilson) – She is the attending general surgeon at
Seattle Grace Hospital. She was always supportive to Chief Webber
especially because she wasn’t afraid to tell him like it is. She is
well-known for her tough and domineering attitude and earned the
nickname The Nazi. She comes across as tough but has softened toward
the residents as she has formed relationships with them. The long
hours spent at work caused problems between her and her husband and
they ended up divorcing. Recently she has started to date Ben Warren
(Jason George).
Richard
Webber (James Pickens, Jr.) – He was the original Chief of Surgery
at Seattle Grace Hospital. Years ago, he had an affair with
Meredith’s mom (Ellis Grey), and the affair contributes to the
tension between him and Meredith at work. He struggled with
alcoholism in the past and when Seattle Grace and Mercy West merged,
it caused him much stress and he ended up falling off the wagon.
Derek Shepherd reported him to the hospital board, and he was
subsequently demoted back to surgeon and told to get help for his
alcoholism. Shepherd took over as acting chief in his absence and
there has been a lot of tension between the two because Webber does
not like the way Shepherd has been running the hospital. Being back
in the OR reminds him of his love for surgery and he and Shepherd
have come to a truce of sorts. Webber has been offering advice on
how to deal with the administrative end of the job.
Mark
Sloan (Eric Dane) – Mark is the head of plastic surgery. His
character ways was a playboy and he even had an affair with Addison
Montgomery Shepherd (Derek’s wife), which ruined his friendship with
Shepherd for quite some time. The femlales at Seattle Grace
nicknamed “McSteamy.”. He started to date Lexie Grey and the
relationship turned serious when they decided to move in together.
He found out he had an 18 year old pregnant daughter when she showed
up on his doorstep, and Lexie had a difficult time adjusting to the
thought of “playing mom.” His daughter’s name is Sloan as well and
he is excited about being a granddad but Sloan wants to give the
baby up for adoption. She ends up leaving without telling him and he
really feels the loss. He starts dating Teddy Altman but explains
that he doesn’t want a fling, he wants a family, which is opposite
of everything he has been up to this point.
Alexandra
‘Lexie” Grey (Chyler Leigh) – She is resident and half-sister to
Meredith (same father). She is known for her photographic memory.
Initially, she and Meredith did not get along but have slowly grown
closer. She dated Mark Sloan for quite some time but it ended when
his 18 year old daughter showed up at his door pregnant and moved in
with them. He was excited about being a grandfather and began to
envision a whole family that Lexie was not ready for. She bolted and
took solace in sleeping with Alex Karev, neither of which is looking
for anything serious. She found out that Sloan moved on with Teddy
Altman and she was upset.
Teddy
Altman (Kim Raver) – She is the head of cardiothoracic surgery at
Seattle Grace. She knows Owen Hunt from the past because they served
together in Iraq. They were in love and she is still in love with
him although he is dating Cristina Yang. She is tough on Yang in
surgery and has different teaching methods than what we are used to,
but Yang wants to scrub in on as many surgeries with her that she
can. Yang offered to trade Owen if she would allow her to scrub in
on surgery. Teddy told Owen this, causing issues between him and
Yang. Currently she is dating Mark Sloan and they are taking it
slowly.
Owen
Hunt (Kevin McKidd) – He is the head of trauma surgery and Yang’s
current boyfriend. He suffers from PTSD (posttraumatic stress
disorder) from his time in Iraq and because of this he almost kills
Yang when he chokes her in his sleep. Yang becomes afraid of him so
he seeks therapy and they are able repair their relationship. He
struggles with memories of Iraq and his time with Altman and their
relationship. He and Yang have a stormy relationship and it almost
ends when she offers to give him to Altman in trade for more surgery
opportunities.
Arizona
Robbins (Jessica Capshaw) – She is the head of pediatric surgery.
She appears calm and able to counsel others through highly emotional
situations. She is currently dating Callie Torres and has helped her
with ‘coming out’ to her dad, although it doesn’t go well at all.
Callie wants kids and she adamantly does not, so this is a point of
contention for their relationship.
Calliope
“Callie” Torres (Sara Ramirez) – She is an attending orthopaedic
surgeon. She got married to George O’Malley but they divorced
because he realized he was in love with Izzie. Callie started a
relationship with Erica Hahn but it was cut short when Hahn left the
hospital over the lack of punishment for Izzie. She has since met
Arizona Robbins and they are dating. She “came out” to her dad, who
was not happy, but after cutting her off from his money and not
speaking to her, he has begun to come around. She and Arizona have
discussed children and Arizona vehemently does not want them. Callie
is upset and ready to end the relationship because she realizes that
she absolutely does want children.
Addison
Montgomery Shepherd (Kate Walsh) – Former head of OB/GYN and
Neonatal Surgery. She was married to Derek Shepherd but they got
divorced due to her infidelity with his best friend Mark Sloan. She
transferred to Seattle Grace and attempted to get back together with
Derek, but she finally realized he was in love with Meredith and
ended up leaving Seattle Grace (she is currently on the spinoff show
Private Practice). She occasionally makes guest appearances on
Grey’s Anatomy.
Isobel
“Izzie” Stevens (Katherine Heigl) – Izzie grew up poor and gave a
daughter up for adoption when she was 16. She started as an intern
at Seattle Grace where she met Denny Duquette, a patient she fell in
love with. He needed a heart transplant and he was not going to get
one in time, so she purposely cut his LVAD wires, causing him to
die. She almost lost her job over this and spiraled into a deep
depression. She began dating Alex Karev and their relationship had
its ups and downs. She was diagnosed with metastatic melanoma and
had to undergo rigorous treatment. They ended up marrying in the
hospital and she underwent surgery, surviving the treatment. Once
back to work, she accidentally induced hyperkalaemia in a patient
slated for renal transplant and therefore lost her job. She left
Seattle Grace without a word to anyone, especially her husband Alex
and has reappeared occasionally. She and Karev have since separated
and she is working at another hospital.
George
O’Malley (T. R. Knight) – George is an intern who was originally
infatuated with Meredith. They ended up sleeping together and she
cried, humiliating him. They were able to get past that and remain
close friends. He was always close friends with Izzie as well. He
began to date Callie Torres, and they ended up getting married. He
began to develop feelings for Izzie, and therefore broke it off with
Callie. They attempted a relationship but realized they were better
off as friends. He died when he tried to save a girl from being hit
by a bus and ended up getting hit instead.
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Meredith
Grey (Ellen Pompeo) – Meredith is the central character and narrates
most of the shows. She began as an intern and is now a resident. She
has had an off and on romance with Derek Shepherd, and they finally
got married by post-it note. She calls herself “dark and stormy,”
mostly due to issues with her alcoholic absent father who she feels
abandoned her many years ago. She also had difficulty reconciling
her mother’s long-term affair with Chief of surgery Richard Webber.
She is best friends with Cristina Yang and they refer to each other
as “my person.” She has a half sister named Lexie and she had
difficulty accepting her when she first came to Seattle Grace
Hospital, but they have slowly grown closer. 
Cristina
Yang (Sandra Oh) – Cristina is a cardiothoracic surgery resident who
is an overachiever. Her life revolves around surgery and she has
been known to put surgery before the relationships in her life. She
is best friends with Meredith Grey. For some time, she had a serious
relationship with Preston Burke but he left her on their wedding
day. She is currently in a relationship with Owen Hunt. He had a
relationship with Teddy Altman in Iraq and there is a bit of a love
triangle between the three. Cristina offers to give Owen to Teddy in
order to scrub in on surgery with Altman as her teacher. She later
works through this with Owen.
Derek
Shepherd (Patrick Dempsey) – He was originally the head of
neurosurgery but took over as chief of surgery when Dr. Webber was
“demoted” due to his alcohol issues. He was nicknamed “McDreamy” by
the girls. He came to Seattle Grace to get away from his ex-wife
Addison, who cheated on him with his best friend Mark Sloan. He
began an on-and-off-again relationship with Meredith and they
recently ended up marrying by post it note. He has been having
issues with Webber since he went to the hospital board about
Webber’s drinking problem, resulting in his demotion. They have been
able to come to a truce and appear to be helping each other through
their trials in their new positions.
Alex
Karev (Justin Chambers) – Alex grew up in an unstable home. He
continuously had to protect his mother from his father, who was
abusive. He had numerous flings with different women at Seattle
Grace Hospital until he met a patient named Ava. She came in with
amnesia and he took care of her, eventually falling in love. Ava
left and later spent some time in a mental hospital and they end up
going their separate ways. He later begins to date Izzie and they
got married while she was in the hospital with cancer. After she was
let go from Seattle Grace for performing an incorrect procedure on a
renal patient, causing her to code and almost die. She then
disappeared and left him floundering. He started sleeping with Lexie.
Miranda
Bailey (Chandra Wilson) – She is the attending general surgeon at
Seattle Grace Hospital. She was always supportive to Chief Webber
especially because she wasn’t afraid to tell him like it is. She is
well-known for her tough and domineering attitude and earned the
nickname The Nazi. She comes across as tough but has softened toward
the residents as she has formed relationships with them. The long
hours spent at work caused problems between her and her husband and
they ended up divorcing. Recently she has started to date Ben Warren
(Jason George). 
Richard
Webber (James Pickens, Jr.) – He was the original Chief of Surgery
at Seattle Grace Hospital. Years ago, he had an affair with
Meredith’s mom (Ellis Grey), and the affair contributes to the
tension between him and Meredith at work. He struggled with
alcoholism in the past and when Seattle Grace and Mercy West merged,
it caused him much stress and he ended up falling off the wagon.
Derek Shepherd reported him to the hospital board, and he was
subsequently demoted back to surgeon and told to get help for his
alcoholism. Shepherd took over as acting chief in his absence and
there has been a lot of tension between the two because Webber does
not like the way Shepherd has been running the hospital. Being back
in the OR reminds him of his love for surgery and he and Shepherd
have come to a truce of sorts. Webber has been offering advice on
how to deal with the administrative end of the job. 
Mark
Sloan (Eric Dane) – Mark is the head of plastic surgery. His
character ways was a playboy and he even had an affair with Addison
Montgomery Shepherd (Derek’s wife), which ruined his friendship with
Shepherd for quite some time. The femlales at Seattle Grace
nicknamed “McSteamy.”. He started to date Lexie Grey and the
relationship turned serious when they decided to move in together.
He found out he had an 18 year old pregnant daughter when she showed
up on his doorstep, and Lexie had a difficult time adjusting to the
thought of “playing mom.” His daughter’s name is Sloan as well and
he is excited about being a granddad but Sloan wants to give the
baby up for adoption. She ends up leaving without telling him and he
really feels the loss. He starts dating Teddy Altman but explains
that he doesn’t want a fling, he wants a family, which is opposite
of everything he has been up to this point.
Alexandra
‘Lexie” Grey (Chyler Leigh) – She is resident and half-sister to
Meredith (same father). She is known for her photographic memory.
Initially, she and Meredith did not get along but have slowly grown
closer. She dated Mark Sloan for quite some time but it ended when
his 18 year old daughter showed up at his door pregnant and moved in
with them. He was excited about being a grandfather and began to
envision a whole family that Lexie was not ready for. She bolted and
took solace in sleeping with Alex Karev, neither of which is looking
for anything serious. She found out that Sloan moved on with Teddy
Altman and she was upset.
Teddy
Altman (Kim Raver) – She is the head of cardiothoracic surgery at
Seattle Grace. She knows Owen Hunt from the past because they served
together in Iraq. They were in love and she is still in love with
him although he is dating Cristina Yang. She is tough on Yang in
surgery and has different teaching methods than what we are used to,
but Yang wants to scrub in on as many surgeries with her that she
can. Yang offered to trade Owen if she would allow her to scrub in
on surgery. Teddy told Owen this, causing issues between him and
Yang. Currently she is dating Mark Sloan and they are taking it
slowly.
Owen
Hunt (Kevin McKidd) – He is the head of trauma surgery and Yang’s
current boyfriend. He suffers from PTSD (posttraumatic stress
disorder) from his time in Iraq and because of this he almost kills
Yang when he chokes her in his sleep. Yang becomes afraid of him so
he seeks therapy and they are able repair their relationship. He
struggles with memories of Iraq and his time with Altman and their
relationship. He and Yang have a stormy relationship and it almost
ends when she offers to give him to Altman in trade for more surgery
opportunities. 
Arizona
Robbins (Jessica Capshaw) – She is the head of pediatric surgery.
She appears calm and able to counsel others through highly emotional
situations. She is currently dating Callie Torres and has helped her
with ‘coming out’ to her dad, although it doesn’t go well at all.
Callie wants kids and she adamantly does not, so this is a point of
contention for their relationship. 
Calliope
“Callie” Torres (Sara Ramirez) – She is an attending orthopaedic
surgeon. She got married to George O’Malley but they divorced
because he realized he was in love with Izzie. Callie started a
relationship with Erica Hahn but it was cut short when Hahn left the
hospital over the lack of punishment for Izzie. She has since met
Arizona Robbins and they are dating. She “came out” to her dad, who
was not happy, but after cutting her off from his money and not
speaking to her, he has begun to come around. She and Arizona have
discussed children and Arizona vehemently does not want them. Callie
is upset and ready to end the relationship because she realizes that
she absolutely does want children.
Addison
Montgomery Shepherd (Kate Walsh) – Former head of OB/GYN and
Neonatal Surgery. She was married to Derek Shepherd but they got
divorced due to her infidelity with his best friend Mark Sloan. She
transferred to Seattle Grace and attempted to get back together with
Derek, but she finally realized he was in love with Meredith and
ended up leaving Seattle Grace (she is currently on the spinoff show
Private Practice). She occasionally makes guest appearances on
Grey’s Anatomy.
Isobel
“Izzie” Stevens (Katherine Heigl) – Izzie grew up poor and gave a
daughter up for adoption when she was 16. She started as an intern
at Seattle Grace where she met Denny Duquette, a patient she fell in
love with. He needed a heart transplant and he was not going to get
one in time, so she purposely cut his LVAD wires, causing him to
die. She almost lost her job over this and spiraled into a deep
depression. She began dating Alex Karev and their relationship had
its ups and downs. She was diagnosed with metastatic melanoma and
had to undergo rigorous treatment. They ended up marrying in the
hospital and she underwent surgery, surviving the treatment. Once
back to work, she accidentally induced hyperkalaemia in a patient
slated for renal transplant and therefore lost her job. She left
Seattle Grace without a word to anyone, especially her husband Alex
and has reappeared occasionally. She and Karev have since separated
and she is working at another hospital.
George
O’Malley (T. R. Knight) – George is an intern who was originally
infatuated with Meredith. They ended up sleeping together and she
cried, humiliating him. They were able to get past that and remain
close friends. He was always close friends with Izzie as well. He
began to date Callie Torres, and they ended up getting married. He
began to develop feelings for Izzie, and therefore broke it off with
Callie. They attempted a relationship but realized they were better
off as friends. He died when he tried to save a girl from being hit
by a bus and ended up getting hit instead.
